Recombinant Mouse Fas/TNFRSF6/CD95 Protein (Fc Tag)

CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized by the presence of an 80 amino acid death domain in its cytoplasmic tail. This domain is essential for the recruitment of a number of signaling components upon activation by either agonistic anti-CD95 antibodies or cognate CD95 ligand that initiate apoptosis. The complex of proteins that forms upon triggering of CD95 is called the death-inducting signaling complex (DISC) . The DISC consists of an adaptor protein and initiator caspases and is essential for induction of apoptosis. CD95 is also crucial for the negative selection of B cells within the germinal center (GC) . Impairment of CD95-mediated apoptosis results in defective affinity maturation and the persistence of autoreactive B-cell clones. Changes in the expression of CD95 and/or its ligand CD95L are frequently found in Human cancer. The downregulation or mutation of CD95 has been proposed as a mechanism by which cancer cells avoid destruction by the immune system through reduced apoptosis sensitivity. Thus , CD95 has therefore been viewed as a tumor suppressor. CD95 has been reported to be involved in the activation of NF-kappaB , MAPK3/ERK1 , MAPK8/JNK , and the alternate pathways for CTL-mediated cytotoxicity. Accordingly , this protein is implicated in the pathogenesis of various malignancies and diseases of the immune system. The CD95/CD95L system was implicated in the etiology of inflammatory bowel disease (IBD) based , primarily , on the finding that CD95 is highly expressed in the intestinal epithelial cells and that epithelial apoptosis is increased in IBD.

Apt; APO; Tumor necrosis factor receptor superfamily member; Tnfrsf; ALPS1A; APO1; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; CD95; FAS1; FASLG receptor; FASR; FASTM; Tumor necrosis factor receptor superfamily member 6; Apt1; Tnfrsf6; Fas; AI196731 Protein; APO1 Protein; APT1 Protein; CD95 Protein; lpr Protein; TNFR6 Protein; Tnfrsf6 Protein

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.