Recombinant Mouse DPPIV/CD26 Protein (His Tag)

Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the N-terminus of polypeptides , such as chemokines , neuropeptides , and peptide hormones. The enzyme is a type II transmembrane glycoprotein , expressed on the surface of many cell types. It is also present in serum and other body fluids in a truncated form (sCD26/DPPIV) . The soluble CD26 (sCD26) as a tumour marker for the detection of colorectal cancer (CRC) and advanced adenomas. As both a regulatory enzyme and a signalling factor , DPP4 has been evaluated and described in many studies. DPP4 inhibition results in increased blood concentration of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) . This causes an increase in glucose-dependent stimulation , resulting in a lowering of blood glucose levels. Recent studies have shown that DPP4 inhibitors can induce a significant reduction in glycosylated haemoglobin (HbA (1c) ) levels , either as monotherapy or as a combination with other antidiabetic agents. Research has also demonstrated that DPP4 inhibitors portray a very low risk of hypoglycaemia development , and are a new pharmacological class of drugs for treating Type 2 diabetes.

DPP; Adenosine Deaminase Complexing Protein; ADCP; ADABP; ADCP2; Adenosine Deaminase Complexing Protein 2; DPPIV; TP103; Cd26; Dpp4; Dipeptidyl peptidase IV (DPP IV) ; THAM

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.