Recombinant Mouse NRG-1 Protein (His Tag)

Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.

Acetylcholine receptor-inducing activity; Acetylcholine receptor-inducing activity; CHICK; homolog of; ARIA; Breast cancer cell differentiation factor p45; GGF; GGF2; Glial growth factor; Heregulin; heregulin; alpha (45kD; ERBB2 p185-activator) ; HGL; HRG; HRG1; HRGA; MST131; NDF; Neu differentiation factor; Neuregulin 1; neuregulin 1 type IV beta 1a; neuregulin 1 type IV beta 3; Neuregulin-1; NRG 1; nrg1; NRG1-IT2; NRG1_HUMAN

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.