Recombinant Human Kallikrein 3/PSA Protein (His Tag)
Product Specifications
Background
KLK3 (Kallikrein Related Peptidase 3) is a Protein Coding gene. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease that is synthesized in the epithelial cells of the prostate gland and is present in seminal plasma. KLK3, also known as Prostate Specific antigen (PSA), kallikrein-related peptidase 3, Gamma-seminoprotein, is a secreted protein of the glandular kallikrein subfamily of serine proteases. KLK3 contains one peptidase S1 domain. KLK3 is a glycoprotein produced almost exclusively by the prostate gland. Growing evidence sμggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers.
Abbreviation
Kallikrein 3/PSA
Synonyms
KLK; Kallikrein; Kallikrein-Related Peptidase; KLK2A; KLK3; APS; KLK2A1; PSA; hK3; Gamma-Seminoprotein; Kallikrein-3; Kallikrein-Related Peptidase 3; P-30 Antigen; Prostate-Specific Antigen; Semenogelase; Seminin; antigen; prostate-specific; APS; Gamma seminoprotein; Gamma-seminoprotein; hK3; Kallikrein 3; Kallikrein related peptidase 3; Kallikrein-3; KLK 3; KLK2A1; Klk3; KLK3; P-30 antigen; P30 antigen; Prostate-specific antigen; Psa; Semenogelase; Seminin
UniProt
P07288
Accession Number
P07288
Expression System
Mammalian
Tag
C-His
Sequence
Met1-Pro261
Field of Research
Neuroscience; Tags & Cell Markers; Signal Transduction; Cancer
Endotoxin
< 1.0 EU/mg of the protein as determined by the LAL method.
Purity
> 90% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
28.6 kDa
Observed Molecular Weight
35 kDa
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Species
Human
Available Sizes
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