Recombinant Human GITR/TNFRSF18 Protein (Fc Tag)

Product Specifications

Background

GITR, also known as TNFRSF18 (CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25 (+) CD4 (+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.

Abbreviation

GITR/TNFRSF18

Synonyms

UNQ; PRO; Tumor necrosis factor receptor superfamily member; Tnfrsf; CD357; Glucocorticoid-induced TNFR-related protein; Tumor necrosis factor receptor superfamily member 18; AITR; GITR; TNFRSF18; UNQ319; PRO364; GITR; AITR

UniProt

Q9Y5U5

Accession Number

Q9Y5U5

Expression System

Mammalian

Tag

C-Fc

Sequence

Gln26-Glu161

Field of Research

Immunology; Signal Transduction; Cancer

Endotoxin

< 1.0 EU/mg of the protein as determined by the LAL method.

Purity

> 90% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.