Recombinant Human GITR Ligand/TNFSF18 Protein (Fc Tag)
Product Specifications
Background
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thoμght to be important for interaction between T lymphocytes and endothelial cells.
Abbreviation
GITR Ligand/TNFSF18
Synonyms
UNQ; PRO; Tnfsf; Activation-inducible TNF-related ligand; Glucocorticoid-induced TNF-related ligand; hGITRL; TNLG2A; AITRL; GITRL; TL6; TNFSF18; UNQ149; PRO175; Activation inducible TNF related ligand; AITR ligand; AITR ligand|GITR ligand|glucocorticoid-induced TNFR-related protein ligand; GITR ligand; Glucocorticoid induced TNF related ligand; Glucocorticoid induced TNFR related protein ligand; MGC138237; TNF18; Tumor necrosis factor (ligand) superfamily member 18; Tumor necrosis factor ligand 2A; Tumor necrosis factor ligand superfamily member 18
UniProt
Q9UNG2
Accession Number
Q9UNG2
Expression System
Mammalian
Tag
C-Fc
Sequence
Glu52-Ser177
Field of Research
Immunology; Tags & Cell Markers; Signal Transduction; Cancer; Cardiovascular
Endotoxin
< 1.0 EU/mg of the protein as determined by the LAL method.
Purity
> 90% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
38.8 kDa
Observed Molecular Weight
40 kDa
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Species
Human
Available Sizes
Documents
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