Recombinant Human ApoA4 Protein (His Tag)
Product Specifications
Background
Apolipoprotein is genetically associated with the risk of Alzheimer's disease (AD) . The APOA1, APOC3, and APOA4 genes are closely linked and located on human chromosome 11. There was a decreased trend for levels of APOA1, APOC3, and APOA4 in AD patients. CONCLUSION: Low levels of APOA1, APOC3, and APOA4 are associated with risk of AD. APOA1, APOC3, and APOA4 should be developed as combined drμgs for the therapy of AD. SNP (single nucleotide polymorphisms) in APOA1and APOA4 genes influences atherogenic characteristics of LDL particles in response to diet.
Abbreviation
ApoA4
Synonyms
Apolipoprotein A; APOA4; Apo AIV; APOA 4; ApoA IV; ApoAIV; ApoA-IV; Apo-AIV; Apolipoprotein A IV; Apolipoprotein A4; Apolipoprotein A-IV; MGC142154; MGC142156; APOA4; Apolipoprotein A-IV; ApoA-IV; ApoAIV; apoA4
UniProt
P06727
Accession Number
P06727
Expression System
Mammalian
Tag
C-His
Sequence
Met1-Ser396
Field of Research
Signal Transduction; Cardiovascular; Cancer; Metabolism
Endotoxin
< 1.0 EU/mg of the protein as determined by the LAL method.
Purity
> 90% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
43.5 kDa
Observed Molecular Weight
45 kDa
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Species
Human
Available Sizes
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