Recombinant Human GASP-1/WFIKKNRP Protein (His Tag)
Product Specifications
Background
WAP , kazal , immunoglobulin , kunitz and NTR domain-containing protein 2 , also known as Growth and differentiation factor-associated serum protein 1 , WAP , follistatin , immunoglobulin , kunitz and NTR domain-containing-related protein , WFIKKN-related protein , WFIKKN2 and GASP1 , is a secreted protein that belongs to the WFIKKN family. WFIKKN2 contains two BPTI/Kunitz inhibitor domains , one Ig-like C2-type (immunoglobulin-like) domain , one Kazal-like domain , one NTR domain and one WAP domain. WFIKKN2 is primarily expressed in ovary , testis and brain , but not in liver. In fetal tissues , it is primarily expressed in brain , skeletal muscle , thymus and kidney. WFIKKN2 is a protease-inhibitor that contains multiple distinct protease inhibitor domains. It probably has serine protease-and metalloprotease-inhibitor activity. It inhibits the biological activity of mature myostatin , but not activin. WFIKKN2 protein binds mature GDF8/myostatin and myostatin propeptide and inhibits the biological activity of myostatin.
Abbreviation
GASP-1/WFIKKNRP
Synonyms
UNQ; GASP; Wfikkn; GASP1; WFIKKNRP; WFIKKN2; UNQ9235; PRO31996; GASP-1; hGASP-1; WFDC20B
UniProt
Q8TEU8
Accession Number
Q8TEU8
Expression System
Mammalian
Tag
C-His
Sequence
Leu35-His576
Endotoxin
< 1.0 EU/mg of the protein as determined by the LAL method.
Purity
> 90% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
59.5 kDa
Observed Molecular Weight
80 kDa
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Species
Human
Available Sizes
Documents
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