Recombinant Human DR6/TNFRSF21 Protein (His Tag)

TNFRSF21 (death receptor-6 , DR6) is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is an extensively posttranslationally modified transmembrane protein and that N-and O-glycosylations of amino acids in its extracellular part. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain , and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production , suggested that DR6 serves as an important regulatory molecule in T-helper cell activation , and is involved in inflammation and immune regulation. DR6 is expressed ubiquitously with high expression in lymphoid organs , heart , brain and pancreas. Some tumor cells overexpress DR6 , typically in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion , which is subject to future investigations.

UNQ; PRO; Death Receptor; Tumor Necrosis Factor Receptor Superfamily Member; TNFRSF; CD358; Death Receptor 6; Tumor Necrosis Factor Receptor Superfamily Member 21; DR6; TNFRSF21; UNQ437; PRO868; DR6; AA959878 Protein; BM 018; BM018; DR 6; DR6 Protein; MGC31965; OTTHUMP00000039915; R74815 Protein; TNFR related death receptor 6; TNFRSF 21; TNFRSF21 protein; TNR21; TR7 Protein; Tumor necrosis factor receptor superfamily member 21 precursor

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.