Recombinant Human CEACAM-1/CD66a Protein (Fc Tag)

The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. CEACAM1 , also known as biliary glycoprotein I (BGP I) and CD66a , is a member of the carcinoembryonic antigen (CEA) gene family which belongs to the immunoglobulin superfamily. The highly glycosylated CEACAM1 contains one N-terminal V-type Ig-like domain and three C2-type Ig-like domains within its ECD , and one ITIM motif and a calmodulin binding site in the cytoplasmic region. CEACAM1 is a surface glycoprotein expressed on various blood cells , epithelial cells , and vascular cells. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners , and was detected on leukocytes , epithelia , and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation , angiogenesis , apoptosis , metastasis , as well as the modulation of innate and adaptive immune responses.

Biliary Glycoprotein; Carcinoembryonic Antigen-Related Cell Adhesion Molecule; CEACAM; CEACAM1; BGP; BGP1; BGPI; BGP-1; Biliary Glycoprotein 1; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1; CD66a; NCA-160; Antigen CD66; BGP 1; Biliary glycoprotein adhesion molecule; Carcinoembryonic antigen related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) ; CD66a antigen; CEAM1; meconium antigen 100

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.