Recombinant Human SEMA3A Protein (Fc Tag)
Product Specifications
Background
This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with an schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with an the progression of Alzheimer's disease.
Abbreviation
SEMA3A
Synonyms
SEMA3A; COLL1; HH16; Hsema-I; Hsema-III; SEMA1; SEMAD; SEMAIII; SEMAL; SemD; coll-1
UniProt
Q14563
Accession Number
Q14563
Expression System
Mammalian
Tag
C-Fc
Sequence
Lys26-Phe546
Field of Research
Cancer; Cardiovascular; Neuroscience
Endotoxin
< 1.0 EU/mg of the protein as determined by the LAL method.
Purity
> 90% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/l00vus
Product MSDS
https://789.bio/eb/LK00Z9
Calculated Molecular Weight
82.2 kDa
Observed Molecular Weight
80-90 kDa
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Species
Human
Available Sizes
Curated Selection
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