Recombinant Human IGFBP2 Protein (His Tag)
Product Specifications
Background
The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II) . The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with an high affinity, or it can remain intracellular, interacting with an many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene.
Abbreviation
IGFBP2
Synonyms
BP 2; BP2; IBP 2; IBP-2; IBP2; IBP2; IGF binding protein 2; IGF BP53; IGF-binding protein 2; IGFBP 2; IGFBP-2; IGFBP2; IGFBP53; Insulin like growth factor binding protein 2 36kDa; Insulin like growth factor binding protein 2; Insulin like growth factor-binding protein 2 precursor ; Insulin-like growth factor-binding protein 2
UniProt
P18065
Accession Number
P18065
Expression System
Mammalian
Tag
C-His
Sequence
Ala36-Gln325
Field of Research
Cancer; Signal transduction
Endotoxin
< 1.0 EU/mg of the protein as determined by the LAL method.
Purity
> 90% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
31.7 kDa
Observed Molecular Weight
35 kDa
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Species
Human
Available Sizes
Documents
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items