Recombinant Rat CCL2/JE/MCP-1 Protein (Trx Tag)

Product Specifications

Background

Monocyte chemoattractant protein 1 (CCL2/JE/MCP-1), also called CCL2, belongs to a group of CC chemokines located in chromosome 17q11.2. CCL2/JE/MCP-1 protein interacts with chemokine C-C motif receptor 2 (CCR2) to activate and recruit monocytes, macrophages, CD4+ T cells and immature dendritic cells to the site of infection. The presence of CCL2/JE/MCP-1 protein in an adequate concentration is important for granuloma formation and M. tuberculosis clearance.

Abbreviation

CCL2/JE/MCP-1

Synonyms

CCL; Scya; C-C motif chemokine; Small-inducible cytokine A; Monocyte chemotactic protein; Monocyte chemoattractant protein; GDCF; HSMCR; GDCF-2; HC11; HSMCR30; MCAF; MCP-1; Monocyte chemotactic protein 1; SMC-CF; Ccl2; C-C motif chemokine 2; Small-inducible cytokine A2; Monocyte chemotactic protein 1 (MCP-1) ; Monocyte chemoattractant protein 1; Immediate-early serum-responsive protein JE; Je; Mcp1; Scya2

UniProt

P14844

Accession Number

P14844

Expression System

E.coli

Tag

N-Trx

Sequence

Gln24-Asn148

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method.

Purity

> 90% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.