Recombinant Human CCL27/CTACK Protein (Sumo Tag)
Product Specifications
Background
CCL27/CTACK, also known as CTACK, is a small cytokine belonging to the CC chemokine family. Members of this family are proteins characterized by two adjacent cysteines. CCL27/CTACK is chemotactic for skin-associated memory T lymphocytes. CCL27/CTACK may also play a role in mediating homing of lymphocytes to cutaneous sites. CCL27/CTACK plays a pivotal role in establishing the inflammatory infiltrate characteristic for common inflammatory skin diseases. Throμgh binding to the chemokine receptor 1 (CCR1), CCL27/CTACK mediates inflammation by promoting lymphocyte migration into the skin.
Abbreviation
CCL27/CTACK
Synonyms
CCL; SCYA; CCL27; ALP; CTACK; CTAK; ESKINE; ILC; PESKY; SCYA27; CC Chemokine ILC; C-C Motif Chemokine 27; Cutaneous T-Cell-Attracting Chemokine; IL-11 R-Alpha-Locus Chemokine; Skinkine; Small-Inducible Cytokine A27; Chemokine (C-C motif) ligand 27; Cutaneous T cell attracting chemokine; IL 11 R alpha locus chemokine; member 27; Small inducible cytokine A27; small inducible cytokine subfamily A (Cys-Cys)
UniProt
Q9Y4X3
Accession Number
Q9Y4X3
Expression System
E.coli
Tag
N-Sumo
Sequence
Phe25-Gly112
Field of Research
Immunology
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 90% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
22.6 kDa
Observed Molecular Weight
28 kDa
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Species
Human
Available Sizes
Documents
Curated Selection
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