Recombinant Human CCL14a/HCC-1 Protein (Sumo Tag)

CCL14a/HCC-1 has an important biological role in other mammals by evolving under positive selection that has been lost in Ochotonidae (subgenera Pika and Lagotona) . CC chemokine ligand 14, CCL14a/HCC-1, is a human CC chemokine that is of recent interest because of its natural ability, upon proteolytic processing of the first eight NH2-terminal residues, to bind to and signal throμgh the human immunodeficiency virus type-1 (HIV-1) co-receptor, CC chemokine receptor 5 (CCR5) . Embryo implantation is a complex process involving blastocyst attachment to the endometrial epithelium and subsequent trophoblast invasion of the decidua. We have previously shown that the chemokines CX3CL1 and CCL14a/HCC-1 are abundant in endometrial vasculature, epithelial, and decidual cells at this time, and that their receptors, CX3CR1 and CCR1, are present on invading human trophoblasts. CX3CL1 and CCL14a/HCC-1 promote trophoblast migration.

CCL; HCC-1/HCC; SCYA; Chemokine CC-1/CC; C-C motif chemokine 14; CC-1; CC-3; Chemokine CC-1/CC-3; HCC-1; HCC-1 (1-74) ; HCC-1/HCC-3; HCC-3; NCC-2; Small-inducible cytokine A14; NCC2; SCYA14; CCL14; CKb1; MCIF; SCYL2

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.