Recombinant Human Galectin-3 Protein (His Tag)
Product Specifications
Background
Galectin-3 (Galectin 3) is a Protein Coding gene. This gene encodes a member of the galectin family of carbohydrate-binding proteins. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. Galectin-3 is a beta-galactoside-binding lectin and plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion, and T-cell regulation. Galectin-3 has an important role in tumor progression throμgh inhibition of apoptosis. Galectin-3 expression is associated with neoplastic transformation and with differentiation of monocytes to macrophages. Elevated expression of Galectin-3 has been demonstrated in the synovium of rheumatoid arthritis (RA) . Diseases associated with Galectin-3 include Follicular Adenoma and Papillary Carcinoma.
Abbreviation
Galectin-3
Synonyms
MAC; Galactose-specific lectin; Galactoside-Binding Soluble; Galectin; Lectin L; GAL; CBP; LGALS3; CBP35; GAL3; GALBP; GALIG; L31; LGALS2; MAC2; Galactoside-Binding Soluble 3; Lectin; Galectin-3; Gal-3; L-31;35 kDa lectin; CBP 35; Galactose-specific lectin 3; IgE-binding protein; Laminin-binding protein; Lectin L-29; Mac-2 antigen; Carbohydrate binding protein 35; Carbohydrate-binding protein 35; galactose binding; galactoside binding soluble 3; Galactoside-binding protein; galectin 3; Galectin 3 internal gene; Galectin3; GBP; IgE binding protein; included; L 31; L 34; L-34 galactoside-binding lectin; Lectin; Galactoside-Binding Soluble 3; LEG3; MAC 2 antigen; Mac-2; Macrophage galactose-specific lectin; MGC105387; P35; soluble 3
UniProt
P17931
Accession Number
P17931
Expression System
E.coli
Tag
N-His
Sequence
2Ala-250Iie
Field of Research
Neuroscience; Cell Biology
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 90% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
27.4 kDa
Observed Molecular Weight
32 kDa
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Species
Human
Available Sizes
Curated Selection
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