Recombinant Human AREG Protein (Trx Tag)
Product Specifications
Background
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha) . The protein interacts with an the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with an a psoriasis-like skin phenotype, and is also associated with an other pathological disorders, including various types of cancers and inflammatory conditions.
Abbreviation
AREG
Synonyms
A REG; Amphiregulin; Amphiregulin B; AR; AREG; AREG; AREGB; Colorectum cell derived growth factor; Colorectum cell-derived growth factor; CRDGF; MGC13647; Schwannoma derived growth factor; SDGF
UniProt
P15514
Accession Number
P15514
Expression System
E.coli
Tag
N-Trx
Sequence
Ser101-Lys184
Field of Research
Cancer; Signal Transduction
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 90% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/xlkcgc
Product MSDS
https://789.bio/eb/aaWeiP
Calculated Molecular Weight
29 kDa
Observed Molecular Weight
29 kDa
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Species
Human
Available Sizes
Curated Selection
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