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SMANT (hydrochloride)

SMANT hydrochloride is a Smoothened (Smo) signaling inhibitor. SMANT hydrochloride is antagonist of Smo accumulation within the primary cilium (PC) . SMANT hydrochloride has an equivalent activity in inhibiting SmoM2 (oncogenic form of Smo) and wild-type Smo[1].

Product Specifications

CAS Number

1177600-74-6

UNSPSC

12352005

Hazard Statement

H302-H361-H372-H410

Target

Hedgehog; Smo

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/smant-hydrochloride.html

Purity

99.90

Solubility

DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1=CC=C(Br)C=C1)CCN2CC(C)CC(C)C2.[H]Cl

Molecular Formula

C16H24BrClN2O

Molecular Weight

375.73

Precautions

P260-P264-P270-P273-P280-P330-P391-P405-P501

References & Citations

[1]Wang Y, et al. Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation. ACS Chem Biol. 2012 Jun 15;7 (6) :1040-8.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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