SMANT (hydrochloride)
SMANT hydrochloride is a Smoothened (Smo) signaling inhibitor. SMANT hydrochloride is antagonist of Smo accumulation within the primary cilium (PC) . SMANT hydrochloride has an equivalent activity in inhibiting SmoM2 (oncogenic form of Smo) and wild-type Smo[1].
Product Specifications
CAS Number
[1177600-74-6]
UNSPSC
12352005
Hazard Statement
H302-H361-H372-H410
Target
Hedgehog; Smo
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/smant-hydrochloride.html
Purity
99.90
Solubility
DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=CC=C(Br)C=C1)CCN2CC(C)CC(C)C2.[H]Cl
Molecular Formula
C16H24BrClN2O
Molecular Weight
375.73
Precautions
P260-P264-P270-P273-P280-P330-P391-P405-P501
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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