KW-2449
KW-2449 is a multi-targeted kinase inhibitor of FLT3, ABL, ABLT315I and Aurora kinase with IC50s of 6.6, 14, 4 and 48 nM, respectively.
Product Specifications
CAS Number
[1000669-72-6]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Apoptosis; Aurora Kinase; Bcr-Abl; FGFR; FLT3
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/KW-2449.html
Purity
99.91
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(C1=CC=C(/C=C/C2=NNC3=C2C=CC=C3)C=C1)N4CCNCC4
Molecular Formula
C20H20N4O
Molecular Weight
332.40
Precautions
H315, H319, H320
References & Citations
[1]Shiotsu Y, et al. KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Blood. 2009 Aug 20;114 (8) :1607-17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Abl; Aurora A
Available Sizes
Curated Selection
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