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Recombinant MAX/MYC associated factor X Monoclonal Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 4. Alternative splicing results in multiple transcript variants.

Abbreviation

MAX

UniProt

P61244

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant Human MAX / MYC associated factor X protein

Target

BHLHd; MAX; bHLHd4; Class D Basic Helix-Loop-Helix Protein 4; Myc-Associated Factor X; Protein Max

Clonality

Monoclonal

Clone

11B4

Conjugation

Unconjugated

Applications

WB; FCM; ICC/IF; IP

Field of Research

Epigenetics and Nuclear Signaling

Purification

Protein A

Concentration

1 mg/mL

Dilution

WB 1:500-1:1000; FCM 1:100-1:500; ICC/IF 1:100-1:500; IP 0.2-1 μL/mg of lysate

Buffer

0.2 μm filtered solution in PBS with 10% Trehalose, pH7.0

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

18 kDa

Observed Molecular Weight

20 kDa

Isotype

IgG

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