Recombinant IL3RA/CD123 Monoclonal Antibody
Product Specifications
Background
CD123 is the 70 kD transmembrane α chain of the IL-3 receptor. Alone, CD123 binds IL-3 with low affinity; when CD123 associates with CDw131 (common β chain), it binds IL-3 with high affinity. CD123 does not transduce intracellular signals upon binding IL-3 and requires the β chain for this function. CD123 is expressed by myeloid precursors, macrophages, dendritic cells, mast cells, basophils, megakaryocytes, and some B cells.
Abbreviation
IL3Ra
UniProt
P26951
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant Human IL3RA protein
Target
IL3RA; CD123; IL3R; IL3RAY; IL3RX; IL3RY; hIL-3Ra; IL-3 Receptor alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R subunitalpha; IL-3RA; IL-3R-alpha; IL-3Receptoralpha; IL-3Rα; IL-4Receptoralpha; IL-5Receptoralpha; IL-6Receptoralpha; IL-7Receptoralpha; Interleukin-3 receptor subunit alpha; IL-3R&alpha
Clonality
Monoclonal
Clone
7C8
Conjugation
Unconjugated
Applications
WB; IP
Field of Research
Immunology; Signal Transduction
Purification
Protein A
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000; IP 0.2-1 μL/mg of lysate
Buffer
0.2 μm filtered solution in PBS
Shipping Conditions
Ice bag
Storage Conditions
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
43 kDa
Observed Molecular Weight
38 kDa
Isotype
IgG
Curated Selection
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