Recombinant VE-Cadherin/CD144/CDH5 Monoclonal Antibody

Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.

CDH; Cadherin 5 Type; cadherin; CDH5;7B4; CD144; cadherin-5; Cadherin 5 Type 2; VE-Cadherin; Cadherin-5;7B 4;7B4 antigen; CADH5; Cadherin 5; Cadherin5; CD 144; CD144 antigen; CDH 5; CDH5 protein; Endothelial specific cadherin; FLJ17376; OTTHUMP00000174777; type 2; type 2 (vascular endothelium) ; vascular endothelial; Vascular endothelial cadherin; Vascular epithelium cadherin; VE Cad; VE cadherin (vascular epithelium) ; VEC

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.