Recombinant Phospho-CrkL (Tyr207) Monoclonal Antibody

Product Specifications

Background

This gene encodes a protein kinase containing SH2 and SH0 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.

Abbreviation

CRKL

UniProt

P46109

Host

Rabbit

Reactivity

Human

Immunogen

A synthetic peptide corresponding to the residues around (Tyr207) of Human Phospho-CrkL

Target

HGNC; CRKL; Crk L; Crk like protein; Crk-like protein; Crkol; HGNC:2363; Oncogene CrkL; V crk avian sarcoma virus CT10 oncogene homolog like; v crk sarcoma virus CT10 oncogene homolog (avian) like; V crk sarcoma virus CT10 oncogene homolog avian like; HGNC:2363

Clonality

Monoclonal

Clone

5B9

Conjugation

Unconjugated

Applications

Field of Research

Neuroscience; Epigenetics and Nuclear Signaling; Signal Transduction; Cancer

Purification

Protein A

Concentration

1 mg/mL

Dilution

WB 1:1000-1:5000

Buffer

10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL protein protectant, 50% glycerol, pH 7.5

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.