Recombinant Phospho-cdc2 (Tyr15) Monoclonal Antibody
Product Specifications
Background
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Abbreviation
CDK1
UniProt
P06493
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic phosphopeptide corresponding to residues around Tyr15 of the Human cdc2
Target
CDC; CDK; CDKN; cyclin-dependent kinase; P34CDC; CDK1; CDC2; CDC28A; P34CDC2; cyclin-dependent kinase 1; CDKN1; CDC2; CDC28A; cyclin-dependent kinase 1; P34CDC2; cyclin dependent kinase 1874
Clonality
Monoclonal
Clone
5B3
Conjugation
Unconjugated
Applications
WB
Field of Research
Cell Biology; Epigenetics and Nuclear Signaling; Cancer; Neuroscience; Metabolism
Purification
Protein A
Concentration
1 mg/mL
Dilution
WB 1:5000-1:50000
Buffer
10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL protein protectant, 50% glycerol, pH 7.5
Shipping Conditions
Ice bag
Storage Conditions
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
34 kDa
Observed Molecular Weight
34 kDa
Isotype
IgG
Available Sizes
Curated Selection
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