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Recombinant Phospho-mTOR (Ser2448) Monoclonal Antibody

Product Specifications

Background

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.

Abbreviation

MTOR

UniProt

P42345

Host

Rabbit

Reactivity

Human

Immunogen

A synthetic peptide corresponding to the residues around Ser2448 of Human Phospho-mTOR

Target

RAFT; RAPT; FK506 binding protein 12-rapamycin associated protein; FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS; mTOR; FK506 binding protein 12-rapamycin associated protein 1; Mechanistic target of rapamycin; dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1) ; FK506 binding protein 12 rapamycin associated protein 1; FK506 binding protein 12 rapamycin associated protein 2; FK506 binding protein 12 rapamycin complex associated protein 1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP rapamycin associated protein; FKBP12 rapamycin complex associated protein; FKBP12-rapamycin complex-associated protein; FKBP12-rapamycin complex-associated protein 1; FLJ44809; Mammalian target of rapamycin; OTTHUMP00000001983; Rapamycin and FKBP12 target 1; Rapamycin associated protein FRAP2; Rapamycin target protein; Rapamycin target protein 1; Serine/threonine-protein kinase mTOR

Clonality

Monoclonal

Clone

4B9

Conjugation

Unconjugated

Applications

WB

Field of Research

Cell Biology; Epigenetics and Nuclear Signaling; Cancer; Cardiovascular; Kits; Lysates; Other; Metabolism

Purification

Protein A

Concentration

1 mg/mL

Dilution

WB 1:2000-1:20000

Buffer

10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL protein protectant, 50% glycerol, pH 7.5

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

280 kDa

Observed Molecular Weight

288 kDa

Isotype

IgG

Available Sizes

Curated Selection

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