Recombinant MMP-2 Monoclonal Antibody

Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is dependent on extracellular matrix metalloproteinase inducer (EMMPRIN), Her2/neu, growth factors, cytokines, and hormones. Pro-MMP-2 activation needs MT1-MMP and TIMP-2 contribution. MMP-2 is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. A low level of MMP-2 is linked to a favorable prognosis in patients with a hormone receptor-negative tumor, usually associated with high risk. As a zymogen requiring proteolytic activation for catalytic activity, MMP-2 has been implicated broadly in the invasion and metastasis of many cancer model systems, including human breast cancer (HBC) . Blocking MMP-2 secretion and activation during breast carcinoma development may decrease metastasis. The detection of active MMP-2 alone or the rate of pro-MMP-2 and active MMP-2 is considered a very sensitive indicator of cancer metastasis. Modulation of MMP-2 expression and activation through specific inhibitors and activators may thus provide a new mechanism for breast cancer treatment.

TBE; CLG; Matrix Metalloproteinase; MMP; CLG4; CLG4A; MMP-2; MMP-II; MONA; TBE-1; MMP2;72 kDa Gelatinase;72 kDa Type IV Collagenase; Gelatinase A; Matrix Metalloproteinase-2;72kD type IV collagenase;72kDa gelatinase;72kDa type IV collagenase) ; CLG 4; CLG 4A; Collagenase Type 4 alpha; Collagenase type IV A; Gelatinase alpha; Gelatinase neutrophil; Matrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenase; Matrix Metalloproteinase 2; Matrix metalloproteinase 2 (gelatinase A; Matrix metalloproteinase II; MMP 2; MMP II; Neutrophil gelatinase; PEX; TBE 1

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.