Recombinant FDPS/Farnesyl Diphosphate Synthase Monoclonal Antibody
Product Specifications
Background
This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 18 and X. Multiple transcript variants encoding different isoforms have been found for this gene.
Abbreviation
FDPS
UniProt
P14324
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant Human FDPS / Farnesyl Diphosphate Synthase protein
Target
KIAA; POROK; FDPS; FPPS; FPS; POROK9; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyl diphosphate synthetase; Farnesyl pyrophosphate synthase; Farnesyl pyrophosphate synthetase; FPP synthase; FPP synthetase; FPPS_HUMAN; Geranyltranstransferase; KIAA1293
Clonality
Monoclonal
Clone
11D13
Conjugation
Unconjugated
Applications
WB; FCM; ICC/IF; IP
Field of Research
Cardiovascular; Signal Transduction; Cancer; Metabolism
Purification
Protein A
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000; FCM 1:25-1:100; ICC/IF 1:20-1:100; IP 1-4 μL/mg of lysate
Buffer
0.2 μm filtered solution in PBS
Shipping Conditions
Ice bag
Storage Conditions
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
48 kDa
Observed Molecular Weight
38 kDa
Isotype
IgG
Available Sizes
Curated Selection
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