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Recombinant FDPS/Farnesyl Diphosphate Synthase Monoclonal Antibody

Product Specifications

Background

This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 18 and X. Multiple transcript variants encoding different isoforms have been found for this gene.

Abbreviation

FDPS

UniProt

P14324

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant Human FDPS / Farnesyl Diphosphate Synthase protein

Target

KIAA; POROK; FDPS; FPPS; FPS; POROK9; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyl diphosphate synthetase; Farnesyl pyrophosphate synthase; Farnesyl pyrophosphate synthetase; FPP synthase; FPP synthetase; FPPS_HUMAN; Geranyltranstransferase; KIAA1293

Clonality

Monoclonal

Clone

11D13

Conjugation

Unconjugated

Applications

WB; FCM; ICC/IF; IP

Field of Research

Cardiovascular; Signal Transduction; Cancer; Metabolism

Purification

Protein A

Concentration

1 mg/mL

Dilution

WB 1:500-1:2000; FCM 1:25-1:100; ICC/IF 1:20-1:100; IP 1-4 μL/mg of lysate

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

48 kDa

Observed Molecular Weight

38 kDa

Isotype

IgG

Available Sizes

Curated Selection

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