Recombinant Phospho-IGF1R (Tyr1131) /Insulin Receptor β (Tyr1146) Monoclonal Antibody

Product Specifications

Background

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Abbreviation

IGF1R

UniProt

P08069

Host

Rabbit

Reactivity

Human

Immunogen

A synthetic phosphopeptide corresponding to residues around Tyr1131 of the Human Phospho-IGF1R or Tyr1146 of the Human Insulin Receptor β

Target

JTK; IGF1R; CD221; IGFIR; IGFR; JTK13; CD221 antigen; IGF-1R; IGF-I R; IGF-I receptor; IGF-IR; insulin-like growth factor 1 receptor

Clonality

Monoclonal

Clone

2C7

Conjugation

Unconjugated

Applications

Field of Research

Signal Transduction; Cancer; Developmental Biology; Neuroscience; Cardiovascular; Metabolism

Purification

Protein A

Concentration

1 mg/mL

Dilution

WB 1:1000-1:10000

Buffer

10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL protein protectant, 50% glycerol, pH 7.5

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.