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PGDH/PHGDH Monoclonal Antibody

Product Specifications

Background

This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known.

Abbreviation

PHGDH

UniProt

O43175

Host

Mouse

Reactivity

Human

Immunogen

Recombinant Human PGDH / PHGDH protein

Target

HEL-S; PHGDH;3-PGDH;3PGDH; HEL-S-113; NLS; NLS1; PDG; PGAD; PGD; PGDH; PHGDHD; SERA; PGDH3

Clonality

Monoclonal

Clone

11B11

Conjugation

Unconjugated

Applications

FCM; ICC/IF

Field of Research

Signal Transduction; Neuroscience; Metabolism

Purification

Protein A

Concentration

1 mg/mL

Dilution

ICC/IF 1:20-1:100; FCM 1:25-1:100

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Isotype

IgG2b

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