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Mesothelin/MSLN Monoclonal Antibody

Product Specifications

Background

This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Abbreviation

MSLN

UniProt

Q13421

Host

Mouse

Reactivity

Human

Immunogen

Recombinant Human Mesothelin/MSLN Protein

Target

CAK; MSLN; MPF; SMRP; CAK1; CAK1 antigen; Megakaryocyte potentiating factor; mesothelin; Pre-pro-megakaryocyte-potentiating factor; SMR; soluble MPF mesothelin related protein; CAK 1; C-ERC/mesothelin; C-ERC/MSLN; cleaved form; Mesothelin isoform 1 precursor; N-ERC/mesothelin; N-ERC/MSLN; Pre pro megakaryocyte potentiating factor

Clonality

Monoclonal

Clone

11B8

Conjugation

Unconjugated

Applications

IHC-P

Field of Research

Tags & Cell Markers; Cancer

Purification

Protein A

Concentration

1 mg/mL

Dilution

IHC-P 1:30-1:100

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Isotype

IgG1

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