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CD19 Monoclonal Antibody

Product Specifications

Background

CD19 protein is a 95 kDa transmembrane glycoprotein that plays a central role in B cell activation and humoral immune responses . CD19 is expressed throughout B cell development from pre-B cells through mature B cells, and it is commonly used as a B cell lineage marker . It is required for the responsiveness of mature B cell to antigen stimulation, germinal center development, and antibody affinity maturation . The CD19 protein associates with the B cell antigen receptor (BCR), CD81, CD38, CD21, CD22, and IFITM1/CD225/Leu13. These associations enable CD19 to amplify B cell signaling and reduce the threshold for antigen stimulation through the BCR.

Abbreviation

CD19

UniProt

P15391

Host

Mouse

Reactivity

Human

Immunogen

Recombinant Human CD19 Protein

Target

CVID; B-lymphocyteantigenCD; B-lymphocyte antigen CD; T-cellsurfaceantigenLeu; Differentiation antigen CD; T-cell surface antigen Leu; B-lymphocytesurfaceantigenB; B-lymphocyte surface antigen B; B4; CVID3; CD19; B-lymphocyteantigenCD19; B-lymphocytesurfaceantigenB4; T-cellsurfaceantigenLeu-12; B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12; B4; CVID3; CD19; CD19 molecule

Clonality

Monoclonal

Clone

5F10

Conjugation

Unconjugated

Applications

WB

Field of Research

Immunology; Stem Cells

Purification

Protein A

Concentration

1 mg/mL

Dilution

WB 1:500-1:2000

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

61 kDa

Observed Molecular Weight

61 kDa

Isotype

IgG1

Available Sizes

Curated Selection

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