IL17RA/CD217 Monoclonal Antibody

Interleukin 17 (also known as CTLA-8) is a T cell-expressed pleotropic cytokine. IL-17 binds to IL-17 receptor A (IL-17 RA), also known as IL-17 receptor (IL-17 R) . IL-17 RA shares no homology with any known family of receptors. While the expression of IL-17 is restricted to activated T cells, the IL-17 RA mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. Human IL-17 RA is a 120 kDa, 866 amino acid (aa) type I membrane glycoprotein with a 293 aa extracellular domain, a 21 aa carboxy-proximal transmembrane domain, and a 525 aa cytoplasmic tail. Within the ECD, human IL-17 RA shares 72% aa sequence identity with mouse and rat IL-17 RA. The signaling events of IL-17 includes activation of NF-kappa B and JNK, and require TNF receptor-associated factors 6 (TRAF6) in the signaling pathway.

IMD; MGC; CTLA; CANDF; CDw; IL17RA; CANDF5; CD217; CDw217; IL-17RA; IL17R; IMD51; hIL-17R; CD127; CD217 antigen; CDW127; CTLA8; HIL 17R; hIL17R; I17RA; IL 17 receptor; IL 17 receptor A; IL 17RA; IL17; IL-17 R alpha; IL-17 receptor A; IL17A receptor; IL-17R; IL17R-A; IL17-RA; IL-17R-alpha; IL7RA; ILRA; Interleukin 17 receptor A; Interleukin-17 receptor A; MGC10262; CDw217; Interleukin-17 receptor A

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.