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NRAS/N-Ras Monoclonal Antibody

Product Specifications

Background

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]

Abbreviation

NRAS

UniProt

P01111

Host

Mouse

Reactivity

Human

Immunogen

Recombinant Human NRAS / N-Ras Protein

Target

ALPS; HRAS; NRAS; ALPS4; CMNS; N-ras; NCMS; NRAS1; NS6; GTPase NRas; GTPase; HRAS1; RASN; Transforming protein N-Ras; AV095280; N ras; N ras protein part 4; Neuroblastoma RAS viral (v ras) oncogene homolog; OTTHUMP00000013879; OTTMUSP00000023521; Transforming protein N Ras; v ras neuroblastoma RAS viral oncogene homolog

Clonality

Monoclonal

Clone

5B12

Conjugation

Unconjugated

Applications

WB

Field of Research

Signal Transduction; Epigenetics and Nuclear Signaling; Cancer; Tags & Cell Markers

Purification

Protein A

Concentration

1 mg/mL

Dilution

WB 1:500-1:2000

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

21 kDa

Observed Molecular Weight

21 kDa

Isotype

IgG1

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