NRAS/N-Ras Monoclonal Antibody
Product Specifications
Background
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
Abbreviation
NRAS
UniProt
P01111
Host
Mouse
Reactivity
Human
Immunogen
Recombinant Human NRAS / N-Ras Protein
Target
ALPS; HRAS; NRAS; ALPS4; CMNS; N-ras; NCMS; NRAS1; NS6; GTPase NRas; GTPase; HRAS1; RASN; Transforming protein N-Ras; AV095280; N ras; N ras protein part 4; Neuroblastoma RAS viral (v ras) oncogene homolog; OTTHUMP00000013879; OTTMUSP00000023521; Transforming protein N Ras; v ras neuroblastoma RAS viral oncogene homolog
Clonality
Monoclonal
Clone
5B12
Conjugation
Unconjugated
Applications
WB
Field of Research
Signal Transduction; Epigenetics and Nuclear Signaling; Cancer; Tags & Cell Markers
Purification
Protein A
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000
Buffer
0.2 μm filtered solution in PBS
Shipping Conditions
Ice bag
Storage Conditions
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
21 kDa
Observed Molecular Weight
21 kDa
Isotype
IgG1
Curated Selection
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