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PARP-1 Monoclonal Antibody

Product Specifications

Background

This gene encodes a chromatin-associated enzyme, poly (ADP-ribosyl) transferase, which modifies various nuclear proteins by poly (ADP-ribosyl) ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Abbreviation

PARP1

UniProt

P09874

Host

Mouse

Reactivity

Human

Immunogen

A synthetic peptide corresponding to the center region of the Human PARP-1

Target

SCA; ARTD; Poly[ADP-ribose] synthase; Poly ADP ribose polymerase; poly (ADP-ribose) polymerase; Poly [ADP-ribose] polymerase; NAD (+) ADP-ribosyltransferase; ADP-ribosyltransferase diphtheria toxin-like; pADPRT; ADPRT; ADPRT 1; ADPRT1; ARTD1; PARP; PARP-1; PPOL; pADPRT-1; PARP1; Cleaved PARP; ADP-ribosyltransferase diphtheria toxin-like 1; APOPAIN; NAD (+) ADP-ribosyltransferase 1; Poly [ADP-ribose] polymerase 1; Poly ADP ribose polymerase 1; poly (ADP-ribose) polymerase 1; Poly[ADP-ribose] synthase 1; SCA1; ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1; PARP; PARP-1; poly (ADP-ribose) polymerase 1; PPOL

Clonality

Monoclonal

Clone

12G7

Conjugation

Unconjugated

Applications

IHC-P

Field of Research

Cell Biology; Epigenetics and Nuclear Signaling; Metabolism; Cancer

Purification

Protein A

Concentration

1 mg/mL

Dilution

IHC-P 1:100-1:500

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Isotype

IgG2a

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