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PARP-1/PARP Monoclonal Antibody

Product Specifications

Background

This gene encodes a chromatin-associated enzyme, poly (ADP-ribosyl) transferase, which modifies various nuclear proteins by poly (ADP-ribosyl) ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Abbreviation

PARP1

UniProt

P09874

Host

Mouse

Reactivity

Human

Immunogen

Recombinant Human PARP-1 / PARP protein

Target

SCA; ARTD; Poly[ADP-ribose] synthase; Poly ADP ribose polymerase; poly (ADP-ribose) polymerase; Poly [ADP-ribose] polymerase; NAD (+) ADP-ribosyltransferase; ADP-ribosyltransferase diphtheria toxin-like; pADPRT; ADPRT; ADPRT 1; ADPRT1; ARTD1; PARP; PARP-1; PPOL; pADPRT-1; PARP1; Cleaved PARP; ADP-ribosyltransferase diphtheria toxin-like 1; APOPAIN; NAD (+) ADP-ribosyltransferase 1; Poly [ADP-ribose] polymerase 1; Poly ADP ribose polymerase 1; poly (ADP-ribose) polymerase 1; Poly[ADP-ribose] synthase 1; SCA1; ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1; PARP; PARP-1; poly (ADP-ribose) polymerase 1; PPOL

Clonality

Monoclonal

Clone

12G6

Conjugation

Unconjugated

Applications

WB; IHC-P; IP

Field of Research

Cell Biology; Epigenetics and Nuclear Signaling; Metabolism; Cancer

Purification

Protein A

Concentration

1 mg/mL

Dilution

WB 1:500-1:1000; IHC-P 1:100-1:500; IP 0.2-1 μL/mg of lysate

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

113 kDa

Observed Molecular Weight

113 kDa

Isotype

IgG1

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