IL-1 beta/IL1B Monoclonal Antibody

Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.

IL1F; IL-1F; pro IL1F; IL-1; IL1-BETA; IL1F2; IL1 beta; IL1B; catabolin; IL-1B; pro Catabolin; pro IL1B; pro IL1F2; pro leukocytic endogenous mediator; pro leukocytic pyrogen; pro lymphocyte activating factor; pro mononuclear cell factor; IL-1F2; IL 1B; IL-1 beta

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.