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PAK1 Antibody Polyclonal Antibody

Product Specifications

Background

P21-activated kinase-1 (PAK1) is an enzyme associated with multiple metabolic networks and different types of cancers.PAK1 (RAC/CDC42-activated kinase 1) is the major oncogenic/ageing kinase, and its dysfunction extends the healthy lifespan of C. elegans by activating HSP16 gene. The p21 protein (Cdc42/Rac) -activated kinase 1 (PAK1) expression appears to be predictive of prognosis in various solid tumors. PAK1 expression may be a predictive marker of overall survival and disease-specific survival in patients with solid tumors.p21-Activated kinase 1 (PAK1) has attracted much attention as a potential therapeutic target due to its central role in many oncogenic signaling pathways, its frequent dysregulation in cancers and neurological disorders, and its tractability as a target for small-molecule inhibition.

Abbreviation

PAK1

UniProt

P35465

Host

Rabbit

Reactivity

Rat

Immunogen

A synthetic peptide corresponding to the C-terminus of the Rat PAK1

Target

PAK; Pak1

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; ICC/IF; IP

Purification

Protein A & Antigen Affinity

Concentration

1 mg/mL

Dilution

WB 1:500-1:1000; ICC/IF 1:1500-1:50000; IP 0.2-1 μL/mg of lysate

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

66 kDa

Observed Molecular Weight

72 kDa

Isotype

IgG

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