4-Hydroxyindole

4-Hydroxyindole is a type of hydroxyindole in which the 1H-indole at position 4 is substituted by a hydroxyl group. 4-Hydroxyindole serves as an important raw material or intermediate in the synthesis of pharmaceutical products and industrial polymers. 4-Hydroxyindole inhibits amyloid fibrillization and induces liver function impairment, thyroid abnormalities, and blood glucose fluctuations in mice. 4-Hydroxyindole holds potential for research in neurodegenerative diseases and metabolic disorders[1][2][3].

Product Specifications

CAS Number

[2380-94-1]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Amyloid-β; Biochemical Assay Reagents

Type

Reference compound

Related Pathways

Neuronal Signaling; Others

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/4-hydroxyindole.html

Purity

99.49

Solubility

DMSO : 15.71 mg/mL (ultrasonic) |H2O : 1.43 mg/mL (ultrasonic)

Smiles

OC1=CC=CC2=C1C=CN2

Molecular Formula

C8H7NO

Molecular Weight

133.15

Precautions

H315, H319, H335

References & Citations

[1]Nenad Manevski, et al. Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases. Drug Metab Dispos. 2010 Mar;38 (3) :386-95.|[2]Cohen T, et al. Inhibition of amyloid fibril formation and cytotoxicity by hydroxyindole derivatives. Biochemistry. 2006 Apr 18;45 (15) :4727-35.|[3]Goyal R N, et al. Electrochemical oxidation of 4-hydroxyindole and effects of its oxidation products on blood parameters of albino mice[J]. Bioorganic Chemistry, 1999, 27 (3) : 239-252.