Succinylsulfathiazole

Succinylsulfathiazole (Succinylsulphathiazole) is a long-acting sulfonamide antibiotic. Succinylsulfathiazole works by inhibiting bacterial folate synthesis through competitive inhibition with P-aminobenzoic acid (PABA) . Succinylsulfathiazole is a gut antiseptic to lower the bacterial load and prevent infections after gut surgeries. Succinylsulfathiazole can produce large shifts in the composition of the gut flora and the ability to synthetize folate[1][2].

Product Specifications

CAS Number

[116-43-8]

Product Name Alternative

Succinylsulphathiazole

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Succinylsulfathiazole.html

Purity

99.22

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C(O)CCC(NC1=CC=C(S(=O)(NC2=NC=CS2)=O)C=C1)=O

Molecular Formula

C13H13N3O5S2

Molecular Weight

355.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Sepehr E, et al. Folate derived from cecal bacterial fermentation does not increase liver folate stores in 28-d folate-depleted male Sprague-Dawley rats. J Nutr. 2003 May;133 (5) :1347-54.|[2]Beydoun S, et al. Succinylsulfathiazole modulates the mTOR signaling pathway in the liver of c57BL/6 mice via a folate independent mechanism. Exp Gerontol. 2021 Jul 15;150:111387.