LAS17

LAS17 is a potent and selective tyrosine-directed irreversible inhibitor for glutathione S-Transferase Pi (GSTP1) [1]. LAS17 inhibits GSTP1 activity with an IC50 of 0.5 μM[2]. LAS17 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[2362527-67-9]

Product Name Alternative

d,l-SKF89976A hydrochloride,E64d; E64c ethyl ester

UNSPSC

12352005

Target

Glutathione S-transferase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/las17.html

Purity

97.46

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)C[C@H](C(OC)=O)N(C1=NC(Cl)=NC(Cl)=N1)CCCC#C

Molecular Formula

C15H20Cl2N4O2

Molecular Weight

359.25

References & Citations

[1]L A Crawford, et al. A tyrosine-reactive irreversible inhibitor for glutathione S-transferase Pi (GSTP1) . Mol Biosyst. 2016 May 24;12 (6) :1768-71.|[2]Sharon M Louie, et al. GSTP1 Is a Driver of Triple-Negative Breast Cancer Cell Metabolism and Pathogenicity. Cell Chem Biol. 2016 May 19;23 (5) :567-578.