HSL-IN-1
HSL-IN-1 (compound 24b) is a potent and orally active hormone sensitive lipase (HSL) inhibitor (IC50=2 nM) with a significantly reduced reactive metabolite liability[1].
Product Specifications
CAS Number
2095156-13-9
UNSPSC
12352005
Target
Lipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/hsl-in-1.html
Concentration
10mM
Purity
99.65
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
O=C(NC1=C(B(O)O)C=C(Cl)C=C1)C(C=C2)=CN=C2OC3=CC=C(C(F)(F)F)C=C3
Molecular Formula
C19H13BClF3N2O4
Molecular Weight
436.58
References & Citations
[1]Ogiyama T, et al. Identification of a novel hormone sensitive lipase inhibitor with a reduced potential of reactive metabolites formation. Bioorg Med Chem. 2017 Apr 1;25 (7) :2234-2243.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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