N, N-Dimethylsphingosine

N, N-Dimethylsphingosine is a potent inhbitor of SphK (sphingosine kinase) as an endogenous metabolite of sphingosine produced in various tissues and tumor cell lines[1].

Product Specifications

CAS Number

[119567-63-4]

UNSPSC

12352211

Hazard Statement

H225, H350

Target

SphK

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-n-dimethylsphingosine.html

Concentration

76.32 mM * 200 μL in Ethanol

Purity

99.93

Solubility

10 mM in DMSO

Smiles

CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N(C)C)CO

Molecular Formula

C20H41NO2

Molecular Weight

327.55

Precautions

H225, H350

References & Citations

[1]Endo K, et al. Cell membrane signaling as target in cancer therapy: inhibitory effect of N, N-dimethyl and N, N, N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice. Cancer Res.