(Z) -Pitavastatin (calcium)

(Z) -Pitavastatin calcium is the Z-Isomer of Pitavastatin hemicacium. Pitavastatin calcium is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin calcium inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells[1].

Product Specifications

CAS Number

[1159588-21-2]

UNSPSC

12352005

Hazard Statement

H302, H361, H362

Target

HMG-CoA Reductase (HMGCR)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/z-pitavastatin-cacium.html

Purity

99.63

Solubility

H2O : 9.09 mg/mL (ultrasonic; adjust pH to 2 with 1 M HCL; heat to 60°C)

Smiles

FC(C=C1)=CC=C1C2=C(/C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)C(C3CC3)=NC4=C2C=CC=C4.[1/2].[Ca+2]

Molecular Formula

C25H24FNO4.1/2Ca

Molecular Weight

440.49

Precautions

H302, H361, H362

References & Citations

[1]Kajinami K, et al. Pitavastatin: efficacy and safety profiles of a novel synthetic HMG-CoA reductase inhibitor.Cardiovasc Drug Rev. 2003 Fall;21 (3) :199-215.