PF-06459988
PF-06459988 is an orally activity, irreversible and mutant-selective inhibitor of EGFR mutant forms. PF-06459988 demonstrates high potency and specificity to the T790M-containing double mutant EGFRs. PF-06459988 can be used for the research of cancer[1].
Product Specifications
CAS Number
1428774-45-1
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PF-06459988.html
Purity
99.10
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C=CC(N1C[C@H](COC2=C3C(NC=C3Cl)=NC(NC4=CN(C)N=C4)=N2)[C@@H](OC)C1)=O
Molecular Formula
C19H22ClN7O3
Molecular Weight
431.88
References & Citations
[1]Cheng H, et al. Discovery of 1-{ (3R,4R) -3-[ ({5-Chloro-2-[ (1-methyl-1H-pyrazol-4-yl) amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy) methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants. J Med Chem. 2016 Mar 10;59 (5) :2005-24. doi: 10.1021/acs.jmedchem.5b01633. Epub 2016 Jan 28.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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