Emeramide

Emeramide is a thiol-redox antioxidant and heavy metal chelator[1].

Product Specifications

CAS Number

[351994-94-0]

Product Name Alternative

NBMI; BDTH2

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Cuproptosis; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Emeramide.html

Purity

99.74

Solubility

DMSO : 100 mg/mL (ultrasonic; warming) |H2O : < 0.1 mg/mL

Smiles

O=C(C1=CC=CC(C(NCCS)=O)=C1)NCCS

Molecular Formula

C12H16N2O2S2

Molecular Weight

284.40

Precautions

H315, H319, H335

References & Citations

[1]Secor JD, et al. Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N, N'-bis (2-mercaptoethyl) isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. Int J Toxicol. 2011 Dec;30 (6) :619-38.|[2]Patel RB, et al. Thiol-redox antioxidants protect against lung vascular endothelial cytoskeletal alterations caused by pulmonary fibrosis inducer, bleomycin: comparison between classical thiol-protectant, N-acetyl-L-cysteine, and novel thiol antioxidant, N, N'-bis-2-mercaptoethyl isophthalamide. Toxicol Mech Methods. 2012 Jun;22 (5) :383-96. |[3]Gadde R, et al. N, N'bis- (2-mercaptoethyl) isophthalamide (NBMI) exerts neuroprotection against lead-induced toxicity in U-87 MG cells. Arch Toxicol. 2021 Aug;95 (8) :2643-2657.|[4]Cheng R, et al. Reversal of genetic brain iron accumulation by N, N'-bis (2-mercaptoethyl) isophthalamide, a lipophilic metal chelator, in mice. Arch Toxicol. 2022 Jul;96 (7) :1951-1962.