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Hit 14

Hit 14 is an inhibitor for C-X-C chemokine receptor type 4 (CXCR4) with IC50 of 254 nM. Hit 14 inhibits the migration and invasion of cell MDA-MB-231. Hit 14 inhibits the Akt phosphorylation, exhibits anti-inflammatory activity, and ameliorateds the ear swelling and damage in mouse models[1].

Product Specifications

CAS Number

440338-68-1

UNSPSC

12352005

Target

Akt; CXCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hit-14.html

Purity

99.0

Smiles

O=S(C1=CC=C(OC2=CC=C(S(=O)(NCC3OCCC3)=O)C=C2)C=C1)(NCC4OCCC4)=O

Molecular Formula

C22H28N2O7S2

Molecular Weight

496.60

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CXCR4

Available Sizes

Frequently Asked Questions

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