Hit 14
Hit 14 is an inhibitor for C-X-C chemokine receptor type 4 (CXCR4) with IC50 of 254 nM. Hit 14 inhibits the migration and invasion of cell MDA-MB-231. Hit 14 inhibits the Akt phosphorylation, exhibits anti-inflammatory activity, and ameliorateds the ear swelling and damage in mouse models[1].
Product Specifications
CAS Number
440338-68-1
UNSPSC
12352005
Target
Akt; CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hit-14.html
Purity
99.0
Smiles
O=S(C1=CC=C(OC2=CC=C(S(=O)(NCC3OCCC3)=O)C=C2)C=C1)(NCC4OCCC4)=O
Molecular Formula
C22H28N2O7S2
Molecular Weight
496.60
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CXCR4
Available Sizes
Frequently Asked Questions
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