AF/LE Purified Anti-Mouse CD105 Antibody[MJ7/18]

Product Specifications

Background

Endoglin (ENG, CD105) is a homodimeric cell membrane glycoprotein of 180 kDa, composed of disulphide-linked subunits of 90-95 kDa. Endoglin is a proliferation-associated and hypoxia-inducible protein mainly expressed on vascular endothelial cells. It acts as an accessory receptor for transforming growth factor beta (TFG-β) and is involved in vascular development and remodelling. The important role of Endoglin in angiogenesis and in tumor progression makes it an ideal target for antiangiogenic therapy and a good marker for tumor prognosis.

Abbreviation

CD105

Gene ID

13805

UniProt

Q63961

Host

Rat

Reactivity

Mouse

Immunogen

Recombinant Human CD105 protein

Target

HHT; ORW1; AI528660; AI662476; CD105; END; Endo; Endoglin; HHT1; ORW; S-endoglin; Edg; Eng; END; HHT1; ORW; ORW1; CD 105; CD105 antigen; EGLN; FLJ41744; Osler Rendu Weber syndrome 1; RP11 228B15.2; SN6

Clonality

Monoclonal

Clone

MJ7/18

Conjugation

None (AF/LE)

Applications

FCM

Purification

>98%, Protein A/G purified

Concentration

≥ 1 mg/mL

Dilution

Buffer

Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.