Purified Anti-Human CD227 Antibody[AR20.5]

MUC-1 (Mucin-1; also PEM, PEMT, Episialin, tumor-associated mucin, and carcinoma associated mucin) is a 240-450 kDa type I transmembrane glycoprotein. Human MUC-1 is 1255 amino acids (aa) in length and contains a 23 aa signal sequence, a 1135 aa extracellular domain (ECD), a 23 aa transmembrane segment, and a 74 aa cytoplasmic tail. The ECD consists of degenerate tandem repeats and a tandem repeat region, which makes up the major portion of the protein. Potential O-glycosylation sites (serines and threonines) make up more than one-fourth of the amino acids. Splicing variants produce ten isoforms for human MUC-1. Human MUC-1 is 28% aa identical to Mouse MUC-1.

MAM; CA 15; MUC; ADMCKD; ADMCKD1; CA 15-3; CD227; EMA; H23AG; KL-6; MAM6; MCD; MCKD; MCKD1; MUC-1; MUC-1/SEC; MUC-1/X; MUC1/ZD; PEM; PEMT; PUM; MUC1; CA15-3; mucin-1; CA15 3; CA153; Episialin; Carcinoma associated mucin; MUC 1; MUC1 beta; MUC1 CT; MUC1 NT; Mucin 1; Peanut reactive urinary mucin; Polymorphic epithelial mucin; Tumor associated mucin; MUC1/CA15-3 C-terminal; EMA; mucin 1; Breast carcinoma-associated antigen DF3; Cancer antigen 15-3; Carcinoma-associated mucin; Krebs von den Lungen-6; Peanut-reactive urinary mucin; Tumor-associated epithelial membrane antigen; Tumor-associated mucin