FASN-IN-4 (tosylate)
Product Specifications
UNSPSC Description
FASN-IN-4 tosylate is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29)[1]. FASN-IN-4 tosylate also inhibits SARS-CoV-2 with an EC50 of 18.6?nM[2].
Target Antigen
Fatty Acid Synthase (FASN); SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection;Metabolic Enzyme/Protease
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/FAS-IN-1-Tosylate.html
Purity
98.55
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
OS(C1=CC=C(C)C=C1)(=O)=O.O=C2COC3(CCN(S(=O)(C4=CC=C(C5=CC=C6C=CC=NC6=C5)C=C4)=O)CC3)CN2C7CC7
Molecular Weight
649.78
References & Citations
[1]Nicholas D. Adams, et al. Fatty acid synthase inhibitors. WO2012064642A1.|[2]Junjun Chu, et al. Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication. Nat Metab. 2021 Nov;3(11):1466-1475.Sci China Life Sci. 2021 May 27;1-21.|Cell Biosci. 2022 Sep 16;12(1):158.|Nat Metab. 2021 Sep 27;1-10.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12648A/FASN-IN-4-tosylate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12648A/FASN-IN-4-tosylate-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2095432-57-6
Available Sizes
Curated Selection
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